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Trials in contexts of high‐mortality diseases are morally suspect because equipoise does not exist between a standard of care that offers little prospect of clinical benefit and a umi that might offer some clinical advantage. Clinical equipoise is an important concept concerning the state of knowledge about a particular research topic (67). In essence, it demands that true ambivalence toward the efficacy of a novel therapy exists among researchers. • the standard of ‘clinical equipoise’ is met “if there is genuine uncertainty within the expert medical community – not necessarily on the part of the individual investigator – about the preferred treatment. ” – freedman, b. (1987) ‘equipoise and the ethics of clinical research’. Abstract the framework of equipoise has been promulgated as an underlying requirement for conducting ethical clinical research. Equipoise is the term used for a state of indifference about which treatment intervention or innovation will provide the most benefit and the least harm to recipients. T1 – equipoise in clinical trials. T2 – angst and progress. Au – rabinstein, alejandro a. Au – brinjikji, waleed. Au – kallmes, david f. N1 – funding information: disclosures dr kallmes received research support from medtronic, microvention, codman, neurosigma, surmodics, sequent medical, and shape memory therapeutics. Definition of clinical equipoise in the definitions. Meaning of clinical equipoise. What does clinical equipoise mean? information and translations of clinical equipoise in the most comprehensive dictionary definitions resource on the web. Equipoise, they correctly asserted, is disturbed by the slightest amount of evidence favoring one arm of the trial (freedman 1987, 141; schafer 1986, 4–6). The doctrine of clinical equipoise is appealing because it appears to permit physicians to maintain their therapeutic obligation to offer optimal medical care to patients while conducting randomized controlled trials (rcts). The appearance, however, is deceptive. Clinical equipoise is based on the uncertainty existing in the expert medical community regarding efficacy (not any individual clinician, researcher or patient). Equipoise provides a sense of balance when doing clinical trials because it is based on the assumption that no particular treatment is better than any other treatment. It is a form of uncertainty regarding which is the best and superior method. Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by benjamin freedman in 1987. More than 30 years ago benjamin freedman writing on ‘equipoise and the ethics of clinical research’ suggested that the concept of ‘clinical equipoise’ should refer to genuine uncertainty in the expert medical community rather than on the part of individual investigators (5)
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